Structural Correlates of Carcinogenesis and Mutagenesis: A Guide to Testing Priorities? : Proceedings of the Second FDA Office of Science Summer Symposium, Held at the US Naval Academy, August 31-September 2, 1977Irvin M. Asher, Constantine Zervos U.S. Department of Health, Education, and Welfare, Public Health Service, Food and Drug Administration, Scientific Liaison Staff, Office of Science, 1978 - 240 pages |
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acyltransferase adducts aflatoxin agents alkylating analysis animal aromatic amines assay atom B. L. Van Duuren benzo(a)pyrene benzylic bioassay biological bond calculated CALIFORNIA LIBRARY Canc Cancer Inst Cancer Res carbonium ion carcino carcinogenesis carcinogenic carcinogenic activity cells CH3 CH3 Chem chemical carcinogens cinogenic compounds correlation derivatives descriptors diol diol epoxides DMBA dose drug effects electrophilic enzyme epoxides equation esters example exposure FDA Rockville FDA Washington Figure genic Hansch human hydrazines hydrocarbons induced interactions J. A. Miller Lijinsky liver mechanisms metabolic metabolic activation metabolites methods methyl mice molecular molecule mouse muta mutagenesis mutagenic Mutagenic activity mutations NIOSH nitrosamines nitrosation non-carcinogenic nucleic acid oxide oxirane parameters partition coefficient potential predict priority problem Proc protein rats reaction reactive ring S-9 mix Salmonella specific structure-activity studies substituent sulfate Symposium tion toxicity tumors typhimurium vinyl chloride vitro vivo Weisburger Zervos